Unveiling Insights: Journey through Scientific Breakthroughs with Papers & Videos
Embark on a knowledge expedition and witness the unfolding stories behind our groundbreaking structures. Our collection of papers and videos serves as a window into the world of cutting-edge structural biology, connecting you with the heart of scientific innovationGPR75
The word‘s first cryo-EM structure of the promising anti-obesity targetIs published by Shuimu
Cryo-EM complex strure of active GPR75 witch a nanbody
November 2023
Published in Molecular Cell
Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5November 22, 2023Published in Nature Portfolio
Novel, broad and potent spike-specific human monoclonal antibodies inhibit SARS-CoV-2 Omicron sub-lineagesNovember 13, 2023Published in BioRxiv
An end-to-end approach for protein folding by integrating Cryo-EM maps and sequence evolutionNovember 5, 2023October 2023
September 2023
Published in Nature Communications
Structural insights into the mechanism of GTP initiation of microtubule assemblySeptember 25, 2023Published in ELife
Carotenoid assembly regulates quinone diffusion and the Roseiflexus castenholzii reaction center-light harvesting complex architectureSeptember 22, 2023Published in Nature Communications
Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signalingSeptember 22, 2023July 2023
June 2023
May 2023
Published in CellResearch
Structure and transport mechanism of the human calcium pump SPCA1May 31, 2023Published in Nature Communications
Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4May 22, 2023Published in Science Advances
Dodecamer assembly of a metazoan AAA+ chaperone couples substrate extraction to refoldingMay 10, 2023April 2023
Published in Communications Biology
HOPE-SIM, a cryo-structured illumination fluorescence microscopy system for accurately targeted cryo-electron tomographyApril 29, 2023Published in Nature Communications
Conformational cycle of human polyamine transporter ATP13A2April 8, 2023Published in ACS
Dual-Affinity Graphene Sheets for High-Resolution Cryo-Electron MicroscopyApril 3, 2023March 2023
January 2023
Published in BioRxiv
Cryo-EM structure of DNA polymerase θ helicase domain in complex with inhibitor novobiocinJanuary 21, 2023Published in Cell Research
The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulationJanuary 17, 2023Published in Cell Discovery
Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5January 7, 2023October 2022
August 2022
June 2022
Published in Nature
Structural insights into dsRNA processing by Drosophila Dicer-2–Loqs-PDJune 29, 2022Published in National Science Review
Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animalsJune 23, 2022Published in Science Advances
Structural insights into G protein activation by D1 dopamine receptorJune 10, 2022Published in Nature Communications
Ligand recognition and biased agonism of the D1 dopamine receptorJune 8, 2022May 2022
Published in PNAS
Structural insights into galanin receptor signalingMay 20, 2022Published in Cell Reports
A highland-adaptation mutation of the Epas1 protein increases its stability and disrupts the circadian clock in the plateau pikaMay 17, 2022Published in Cell Discovery
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3May 15, 2022April 2022
February 2022
Published in bioRxiv preprint
Structure of IgG-Fc hexamer reveals a mutual lock-and-key mode of Fc-Fc interaction February 25, 2022Published in Nature Communications
Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2February 25, 2022Published in Cell
Receptor binding and complex structures of human ACE2 to spike RBD from Omicron and Delta SARS-CoV-2February 17, 2022Published in Journal of Virology
Structure of Rift Valley fever virus RNA-dependent RNA polymerase February 9, 2022December 2021
September 2021
Published in ACS nano
Atomically Thin Bilayer Janus Membranes for Cryo-electron MicroscopySeptember 27, 2021Published in Molecular Biomedicine
Fast and long-lasting immune response to S-trimer COVID-19 vaccine adjuvanted by PIKASeptember 27, 2021Published in Nature
Structures of full-length glycoprotein hormone receptor signalling complexesSeptember 22, 2021Published in Nature Structural&Molecular Biology
Molecular basis for kinin selectivity and activation of the human bradykinin receptorsSeptember 9, 2021April 2021
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