300kV cryo-EM Instrument Booking and Data Collection
The Shuimu BioSciences Cryo-EM Center boasts eight state-of-the-art 300kV cryoEM and comprehensive gear. We offer global clients easy booking and high-throughput data collection focusing on quality expedites structure analysis.Advantages of
Our Services
24/7 Service
- We have a robust appointment system tailored to your scheduling preferences.
- Our commitment is to respond to appointment requests no more than 24 hours, providing an expedited channel that allows scheduling data collection service within as little as 3 days.
Prioritize Customer Needs
- Our services encompass both online remote hole selection and the guidance of Shuimu scientists in hole selection, ensuring the maximization of data utilization to meet your specific needs.
- Our team of experienced technical experts maintains a high level of professionalism in all cryoEM operations, delivering prompt responses to unforeseen situations that may occur throughout the data collection process.
AI Driven Platform
- The SMART software series, developed independently by Shuimu, is designed to enhance the efficiency of the entire cryoEM data analysis process. This software generates models with superior resolution using fewer machine hours and data, ensuring an optimal experience for our valued customers.
Daily Platform Maintenance
- Regular, high-frequency maintenance is conducted to ensure optimal performance, guaranteeing the efficiency and quality of data collection.
8
300kv Krios cryo-EM200+
Single Particle Projects150+
Structures better than 3.5Å1.5Å
Highest Resolution Obtained51kDa
Smallest Protein analyzedBusiness Process
Free cryo-sample freezing service available
Note: Instrument booking is done on a daily basis (from 9:00 AM on day T to 9:00 AM on day T+1)Project consultation and communication
Instrument booking
Contract and payment
Instrument Scheduling
Grid submission and delivery
Data collection
Data delivery
Hardware Configuration of Cryo-EM Center
Shuimu owns the world's largest and most advanced biopolymer imaging equipment, featuring top-tier hardware and software for superior imaging quality.
Daily inspections and maintenance ensure optimal performance, maintaining each microscope's availability at over 330 days per year. The annual trouble-free operation rate exceeds 97%.Falcon 4 camera
C-CFEG (cold field-emission electron gun) Electron Source
Selectris X imaging filter
AutoLoader
Pre-tilt Sample Holder (±70°)
Configured software for EPU, Tomography & Velox
AFIS (aberration-free image shift)
FFI (fringe free imaging)
Maximum Operational Efficiency: 8000 Pics / Day
A glance of our CryoEM Platform
Reference
Wang H, Lv S, Stroebel D, et al. Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors[J]. Neuron, 2021.
Xia R, Wang N, Xu Z, et al. Cryo-EM structure of the human histamine H 1 receptor/G q complex[J]. Nature communications, 2021, 12(1): 1-9.
Yin Y L, Ye C, Zhou F, et al. Molecular basis for kinin selectivity and activation of the human bradykinin receptors [J]. Nature Structural & Molecular Biology, 2021, 28: 755-761.
Ma X, Zou F, Yu F, et al. Nanoparticle vaccines based on the receptor binding domain (RBD) and heptad repeat (HR) of SARS-CoV-2 elicit robust protective immune responses[J]. Immunity, 2020, 53(6): 1315-1330. e9.
Du S, Liu P, Zhang Z, et al. Structures of SARS-CoV-2 B. 1.351 neutralizing antibodies provide insights into cocktail design against concerning variants[J]. Cell Research, 2021: 1-4.
Nie J, Xie J, Liu S, et al. Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutants[J]. Cell Discovery, 2021, 7(1): 1-11.
Song D, Wang W, Dong C, et al. Structure and function analysis of a potent human neutralizing antibody CA521 FALA against SARS-CoV-2[J]. Communications biology, 2021, 4(1): 1-11.
Ma J, Su D, Sun Y, et al. Cryo-electron Microscopy Structure of S-Trimer, a Subunit Vaccine Candidate for COVID-19[J]. Journal of Virology, 2021, 95(11): e00194-21.
See Unseeable.
Drug Undruggable.
Founded in 2017, Shuimu BioSciences aims to bring the power of cryo-EM to innovative therapeutics developers.Contacts
1 Broadway 5th floor, Cambridge, MA 02142, United States+1 (650) 680 9298
Hi@shuimubio.com
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